Boosters perform well, autoimmunity remains the best drug
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On May 10, the National Center for Infectious Diseases Medical Center and the information release platform "Huashan Infection" of the Department of Infectious Diseases of Huashan Hospital Affiliated to Fudan University announced a new research result, which confirmed the effectiveness of strengthening vaccination against multiple mutant strains of Omicron. necessity. Huashan Infection Professor Zhang Wenhong's team and Fudan University's School of Life Sciences Professor Wang Pengfei's team worked together to evaluate the immune escape characteristics of the four subtypes of the Omicron variant against two doses of inactivated vaccine and the third booster vaccination.
The related results were published in the journal Cell Host and Microbe on May 8 (2021 IF 21.023).
This study found that the antibody titer level of the subjects after two doses of inactivated vaccine to the Omicron strain was at least 5.3 times lower than that of the original strain . The pseudovirus experimental evaluation of the four subtypes showed that neutralizing antibody titers against BA.2 were similar to BA.1, or lower than BA.1.
After the third dose of homologous (inactivated vaccine) or heterologous vaccination, the antibody titer increased significantly, and the antibody positive rate reached at least 75%. In addition, antibody escape of the three recombinant lineages XD, XE, XF is not expected to be significantly different from the four Omicron sublines studied because their S proteins are identical to BA.1 or BA.2.
In December 2021, Professor Zhang Wenhong's team and Professor Wang Pengfei's team of Huashan infected both evaluated the neutralization ability of Omicron BA.1 strain in serum samples of two doses of inactivated vaccine and three doses of homologous/heterologous inoculation.
The study found that the antibody titer of the two-shot inactivated vaccine against the Omicron variant decreased significantly, and the neutralizing antibody titer dropped to 6.04, about 10 times lower than the original strain . Regardless of the type of the third booster (inactivated vaccine or recombinant subunit protein vaccine), the positive rate of neutralizing antibody titers of serum samples to Omicron strain reached 100%.
Simply put, the core content of this paper is three points : 1. The new Omicron mutants have similar antibody escapes to the current BA.1 and BA.2 mutants; 2. The two previous inoculations were directed against The neutralizing ability of the antibody against Omicron is greatly reduced; 3. The ability to strengthen the neutralizing antibody against Omicron is very good.
Needless to say, the next conclusion is to call for a quick booster vaccination. Simply put, everyone continues to get vaccinated as soon as possible. So on the question of whether it is necessary to vaccinate the current vaccine, everyone decides on their own.
I think Dr. Zhang has said publicly before, what is the best medicine in the world? It is the body's own immune system . In the European and American markets, the research and development cycle of new drugs is generally more than 10 years, and the innovative vaccines generally take 8 to 12 years (as follows: 14 years for influenza vaccine, 23 years for HPV vaccine, and 38 years for hepatitis B vaccine), of which the preclinical research stage is 1-12 years. 10 years, clinical trials 4-7 years.
Of course, the United States has also successfully developed the COVID-19 vaccine this time. To be precise, these vaccines in the United States are only in the preclinical research stage, because it takes 1-10 years to study various potential preclinical studies . Caused problems, and then it takes 4-7 years for the clinic to find side effects and constantly adjust. But because the epidemic was jointly operated by the U.S. government, the FDA and pharmaceutical companies, the vaccine received miraculously quickly.
As a result, the follow-up study reports of various vaccines in the United States have now come out, and it has been found that the various side effects are very large, and the vaccines in the United States are simply substandard vaccines . Therefore, medical experts in the United States found that there is a big problem in the development of this vaccine. It is impossible to be fast at all. Behind the fast is to accept all the side effects.
At present, the American people completely no longer believe in this rapid vaccine. If the vaccine can really be so rapid, wouldn't the cancer be conquered immediately? According to the speed of the vaccine, it can be released in one year, which means that a targeted drug can be obtained in one year. Can we human beings be able to greatly extend our lifespan immediately? Obviously this is not possible. This is the root cause of the current opposition to COVID-19 vaccination in the United States.
In many cases, things that go against the normal R&D cycle do not mean that they cannot come out, but that they need to pay a corresponding price. So whether it is necessary to vaccinate Omicron, which has evolved into an upper respiratory disease, everyone should think for themselves. There has never been a continuous injection of vaccines in human history, and it is now becoming a new history in the history of medicine. Finally, let’s talk about raising chickens. Can I enter the restaurant for you to eat in 40 days? Of course I can, and then what happens when children often eat it? This is the price.